Increased Conversion Ratio of Tryptophan to Niacin by Dietary Di-n-butylphthalate.
نویسندگان
چکیده
منابع مشابه
Reproductive toxicology. Di-n-butylphthalate, mice.
Background: Studies of association methods using DNA pooling of single nucleotide polymorphisms (SNPs) have focused primarily on the effects of "machine-error", number of replicates, and the size of the pool. We use the non-centrality parameter (NCP) for the analysis of variance test to compute the approximate power for genetic association tests with DNA pooling data on cases and controls. We i...
متن کاملReproductive toxicology. Di-n-butylphthalate, rats.
Di-n-butylphthalate (DBP) was tested using the standard RACB protocol in SpragueDawley rats. This was the second study to use Sprague-Dawley rats, and was conducted to generate some information on the relative susceptibility of adult versus juvenile plus adult exposure scenarios, and to develop some data in a second species. Body weights, food and water consumptions, and dinical signs in the do...
متن کاملConversion of monomethyl-l-tryptophan to niacin and N1-methylnicotinamide by the rat.
Gordon and Jackson (1) found that synthetic monomethyltryptophan was capable of stimulating growth in rats subsisting on a diet deficient in tryptophan. Chin (2) isolated kynurenine and kynurenic acid from the urine of rabbits after the parenteral administration of monomethylL-tryptophan (MMT). On the other hand, recent studies have shown that the albino rat, pig, horse, cotton-rat, and man can...
متن کاملNiacin in Rats
We have previously reported that the administration of a large amount of di(n-blltyl)phthalftte (DBP) increased the conversion ratio of tryptophan to niacin in rats. In the present experiment, the effect of di(2-ethylhexyl)phthalate (DEHP) on the conyersion ratio and how altering the conversion ratio of tryptophan to niacin depended on the concentration of DEHP were inyestigated to elucidate th...
متن کاملIn vivo and in vitro percutaneous absorption of [(14)C]di-N-butylphthalate in rat.
This study evaluated the toxicokinetics of [(14)C]di-n-butylphthalate ([(14)C]DBP) after an intravenous administration (1 and 10 mg/kg, in Cremophor) or a topical application (10 microl/cm(2); 10 cm(2), neat) in haired male Sprague-Dawley rats. Additional in vivo and in vitro percutaneous penetration studies of [(14)C]DBP were conducted on male and female haired rats and male hairless rats. Aft...
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ژورنال
عنوان ژورنال: Journal of Nutritional Science and Vitaminology
سال: 2001
ISSN: 0301-4800,1881-7742
DOI: 10.3177/jnsv.47.263